Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance

@inproceedings{Zhang2016SkeletalMT,
  title={Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance},
  author={Wei Zhang and Mengrui Wu and Teayoun Kim and Ravi H. Jariwala and W. John Garvey and Nanlan Luo and Minsung Kang and Elizabeth Ma and Ling Tian and Dennis Steverson and Qinglin Yang and Yuchang Fu and W Timothy Garvey},
  booktitle={Diabetes},
  year={2016}
}
In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout (MKO) mice to determine whether TRIB3 mediates glucose-induced insulin resistance in diabetes and whether alterations in TRIB3 expression as a function of nutrient availability have a regulatory role in metabolism. In streptozotocin diabetic mice, TRIB3 MOE exacerbated, whereas MKO prevented, glucose-induced insulin resistance and impaired glucose oxidation and defects in insulin signal transduction compared… CONTINUE READING
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