Skeletal Muscle Relaxants

@article{See2008SkeletalMR,
  title={Skeletal Muscle Relaxants},
  author={Sharon See and Regina Ginzburg},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2008},
  volume={28}
}
  • S. See, Regina Ginzburg
  • Published 1 February 2008
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Health care providers prescribe skeletal muscle relaxants for a variety of indications. However, the comparative efficacy of these drugs is not well known. Skeletal muscle relaxants consist of both antispasticity and antispasmodic agents, a distinction prescribers often overlook. The antispasticity agents—baclofen, tizanidine, dantrolene, and diazepam—aid in improving muscle hypertonicity and involuntary jerks. Antispasmodic agents, such as cyclobenzaprine, are primarily used to treat… 
Antispasmodics and Muscle Relaxants
TLDR
Most guidelines and current evidence support short-term use for all medications discussed in this chapter, and there is no clear evidence to show superiority of one muscle relaxant over another in managing acute low back pain.
APPROACHES FOR THE DELIVERY OF SKELETAL MUSCLE RELAXANTS: A REVIEW
TLDR
The outcome of different techniques adopted in delivering the skeletal muscle relaxants through different routes of administration are discussed with an aim of lowering the side effects and providing sufficient concentration of drug in the body.
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TLDR
Muscle relaxant use was common in hemodialysis patients and associated with altered mental status and falls and the lower risk for death with muscle relaxants may have been the result of residual confounding.
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Skeletal muscle relaxants (myorelaxants) are a group of chemical compounds that act both centrally and peripherally and have the ability to relax skeletal muscle, which reduces muscle contractility
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TLDR
More high-quality clinical trials and systematic reviews are needed in several drug classes to assess the potential for benefit and risk of harm with respect to perioperative multimodal analgesia.
Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain.
TLDR
For patients with low back pain, skeletal muscle relaxants are often initiated after failure of first-line analgesics, but these medications are controversial alternatives that carry risks of adverse effects and increased cost.
Injury in an Elderly Population Before and After Initiating a Skeletal Muscle Relaxant
TLDR
Cautionary use of these medications in the elderly continues to be advisable, but their use in selected patients 65 years and older could be considered if the expected benefits outweigh the small increased risk of injury.
Risk of Opioid Overdose Associated With Concomitant Use of Opioids and Skeletal Muscle Relaxants: A Population‐Based Cohort Study
TLDR
Clinicians should be cautious about concomitant use of opioids and skeletal muscle relaxants given the additive central nervous system depressant effect to optimize pain care and improve patient safety.
TREATMENT OF PAIN: CURRENT CONCEPTS IN PHARMACOTHERAPY*
TLDR
The therapeutic application of a variety of analgesics available for the treatment of pain are reviewed, and a brief discussion of tapentadol, a new opioid analgesic with a dual mechanism of action is included.
Análise dos medicamentos relaxantes musculares de ação central comercializados no Brasil na perspectiva do Cuidado ao Idoso
TLDR
Evidence for the use of musclerelaxants in the elderly is limited and the package leaflets do not contain relevant information on adverse events.
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