Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance.

@article{Molina2016SkeletalMM,
  title={Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance.},
  author={Anthony J A Molina and Manish S. Bharadwaj and Cynthia G Van Horn and Barbara J Nicklas and Mary F. Lyles and Joel D Eggebeen and Mark Joseph Franklin Haykowsky and Peter H. Brubaker and Dalane W. Kitzman},
  journal={JACC. Heart failure},
  year={2016},
  volume={4 8},
  pages={636-45}
}
OBJECTIVES The aim of this study was to examine skeletal muscle mitochondria content, oxidative capacity, and the expression of key mitochondrial dynamics proteins in patients with heart failure with preserved ejection fraction (HFpEF), as well as to determine potential relationships with measures of exercise performance. BACKGROUND Multiple lines of evidence indicate that severely reduced peak exercise oxygen uptake (peak VO2) in older patients with HFpEF is related to abnormal skeletal… CONTINUE READING
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Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults

  • DJ Tyrrell, MS Bharadwaj, CG Van Horn, SB Kritchevsky, BJ Nicklas, AJ. Molina
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  • 2015
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