Skeletal Muscle Denervation Activates Acetylcholine Receptor Genes

  title={Skeletal Muscle Denervation Activates Acetylcholine Receptor Genes},
  • Published 2002
Transcriptional activity of acetylcholine receptor subunit genes was investigated in innervated and denervated chick skeletal muscle. The sciatic nerve of 3-d-old White Leghorn chicks was sectioned unilaterally; after various intervals, nuclei were isolated from operated and sham-operated animals, and run-on assays performed. Nuclei were incubated with 32p-UTP, and total RNA was extracted and hybridized onto filters containing an excess of subunit-specific DNA. Specific transcripts were… CONTINUE READING
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