Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes

@article{Ueta2001SkeletalMC,
  title={Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes},
  author={Chisato Ueta and Masahiro Iwamoto and Naoko Kanatani and Carolina Andrea Yoshida and Yang Liu and Motomi Enomoto-Iwamoto and Tomoharu Ohmori and Hirayuki Enomoto and Ken Nakata and Kenji Takada and Kojiro Kurisu and Toshihisa Komori},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={153},
  pages={87 - 100}
}
During skeletogenesis, cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone. However, the mechanism by which cartilage phenotype is specified remains unclarified. Core binding factor alpha1 (Cbfa1) is an essential transcription factor for osteoblast differentiation and bone formation and has the ability to stimulate chondrocyte maturation in vitro. To understand the roles of Cbfa1 in chondrocytes during skeletal… CONTINUE READING

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CartilageSibling in is aJoints
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
JointsSibling in is aCartilage
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
CartilageSibling in is aSkeletal bone
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
Skeletal boneSibling in is aCartilage
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
CartilageSibling in is aBone Tissue
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
Bone TissueSibling in is aCartilage
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
During skeletogenesis , cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
JointsSibling in is aSkeletal bone
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
Skeletal boneSibling in is aJoints
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
Core binding factor alpha1 ( Cbfa1 ) is an essential transcription factor for osteoblast differentiation and bone formation and has the ability to stimulate chondrocyte maturation in vitro .
Cbfa1 overexpression caused acceleration of endochondral ossification due to precocious chondrocyte maturation , whereas overexpression of DN - Cbfa1 suppressed maturation and delayed endochondral ossification .
Cbfa1 overexpression caused acceleration of endochondral ossification due to precocious chondrocyte maturation , whereas overexpression of DN - Cbfa1 suppressed maturation and delayed endochondral ossification .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis , including formation of joints , permanent cartilages , and endochondral bones .
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