Sjögren syndrome

@article{BritoZern2016SjgrenS,
  title={Sj{\"o}gren syndrome},
  author={Pilar Brito-Zer{\'o}n and Chiara Baldini and Hendrika Bootsma and Simon J. Bowman and Roland Jonsson and Xavier Mariette and Kathy L. Moser Sivils and Elke Theander and Athanasios G. Tzioufas and Manuel Ramos-Casals},
  journal={Nature Reviews Disease Primers},
  year={2016},
  volume={2}
}
Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally in the mouth and eyes. This disease predominantly affects middle-aged women, but can also be observed in children, men and the elderly. The clinical presentation of SjS is heterogeneous and can vary from sicca symptoms to systemic disease (characterized by peri-epithelial lymphocytic… 
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References

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Sjögren syndrome.
TLDR
Activated lymphocytes in patients with autoimmune diseases appear to have selective homing into the lacrimal and salivary glands leading to tissue damage in Sjögren syndrome.
Sjögren’s Syndrome or Autoimmune Epithelitis?
  • H. Moutsopoulos
  • Medicine, Biology
    Clinical immunology and immunopathology
  • 1994
TLDR
Clinical studies suggest that the majority of extraglandular manifestations of SS are due to the attraction of lymphocytes by different epithelial tissues and thus the descriptive term "autoimmune epithelitis" instead of "Sjögren's syndrome" is proposed.
Sjögren's syndrome, the old and the new.
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Sjögren syndrome: what and where are we looking for?
TLDR
Great advances have been seen in the role of inflammation in ocular, oral and extra-glandular manifestations of Sjögren's syndrome as well as in the correlation correspondence to human disease.
Sjögren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems
TLDR
Patients with Sjo¨gren's syndrome have focal lymphocytic infiltrates and partial destruction of glandular secretory units, and the ability to modulate immune response and stimulate residual glandular elements provides new therapeutic opportunities.
Urban legends series: Sjögren's syndrome.
TLDR
Results from literature searches suggested that anti α-fodrin IgA and anti-MR3 autoantibodies seem to be promising diagnostic markers of SjS, but more studies are warranted to test their sensitivity and specificity.
Early diagnosis of primary Sjögren’s syndrome: EULAR-SS task force clinical recommendations
TLDR
This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis.
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