Sjögren syndrome

  title={Sj{\"o}gren syndrome},
  author={Pilar Brito-Zer{\'o}n and Chiara Baldini and Hendrika Bootsma and Simon J. Bowman and Roland Jonsson and Xavier Mariette and Kathy L. Moser Sivils and Elke Theander and Athanasios G. Tzioufas and Manuel Ramos-Casals},
  journal={Nature Reviews Disease Primers},
Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally in the mouth and eyes. This disease predominantly affects middle-aged women, but can also be observed in children, men and the elderly. The clinical presentation of SjS is heterogeneous and can vary from sicca symptoms to systemic disease (characterized by peri-epithelial lymphocytic… 
Primary Sjögren Syndrome: A review for health professionals
The dentist plays an important role within the multidisciplinary team, with meticulous instructions on oral hygiene, non-cariogenic diet advice, prescription lubricating agents and constant evaluation of dental restorations to give the patients a better health wellbeing.
Clinical Aspects of Sjögren's
Sjögren’s syndrome: a systemic autoimmune disease
The objective of this review paper is to summarize the recent literature on Sjögren’s syndrome, starting from its pathogenesis to current therapeutic options.
Mouse Models of Primary Sjogren's Syndrome.
This review focuses on recent mouse models of primary SjS xerostomia and describes them under three categories of spontaneous, genetically engineered, and experimentally induced models.
The Involvement of Alarmins in the Pathogenesis of Sjögren’s Syndrome
The crucial role of innate immunity has been advocated in recent years regarding the pathogenesis of pSS, especially in the initiation and progression toward autoimmunity.
Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation
Evidence from recent clinical trials investigating biological therapy in primary Sjögren's syndrome is summarized, specifically highlighting efficacy, or lack thereof, in modulating local inflammation and improving salivary gland function.
Lymphoma and Lymphomagenesis in Primary Sjögren’s Syndrome
This review article encompasses the body of evidence published so far in this field highlighting the challenges and pitfalls of different biomarkers within clinical practice and provides an overview of epidemiological data, diagnostic procedures, and evidence-based treatment strategies for NHL in pSS.
Innate Immunity and Biological Therapies for the Treatment of Sjögren’s Syndrome
The role of different immune cells in disease development, therapeutic treatments, and future strategies that are available to target various immune cells to cure the disease are highlighted.
Immunobiology of T Cells in Sjögren’s Syndrome
This review comprehensively summarizes the research progress and the understanding of T cells in SjS, including CD4 + T cells, CD8 + T RM cells, and innate T Cells, to provide insights into for clinical treatment.
Inflammation in Sjögren's syndrome: Cause or consequence?
An overview of Sjögren’s syndrome aims to better elucidate this local and systemic disease, which can be of vital use not only for SS but also to other rheumatic pathological conditions.


Sjögren syndrome.
Activated lymphocytes in patients with autoimmune diseases appear to have selective homing into the lacrimal and salivary glands leading to tissue damage in Sjögren syndrome.
Sjögren’s Syndrome or Autoimmune Epithelitis?
  • H. Moutsopoulos
  • Medicine, Biology
    Clinical immunology and immunopathology
  • 1994
Clinical studies suggest that the majority of extraglandular manifestations of SS are due to the attraction of lymphocytes by different epithelial tissues and thus the descriptive term "autoimmune epithelitis" instead of "Sjögren's syndrome" is proposed.
Sjögren's syndrome, the old and the new.
New concepts in the pathogenesis of Sjögren's syndrome.
Sjögren syndrome: what and where are we looking for?
Great advances have been seen in the role of inflammation in ocular, oral and extra-glandular manifestations of Sjögren's syndrome as well as in the correlation correspondence to human disease.
Sjögren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems
Patients with Sjo¨gren's syndrome have focal lymphocytic infiltrates and partial destruction of glandular secretory units, and the ability to modulate immune response and stimulate residual glandular elements provides new therapeutic opportunities.
Urban legends series: Sjögren's syndrome.
Results from literature searches suggested that anti α-fodrin IgA and anti-MR3 autoantibodies seem to be promising diagnostic markers of SjS, but more studies are warranted to test their sensitivity and specificity.
Early diagnosis of primary Sjögren’s syndrome: EULAR-SS task force clinical recommendations
This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis.