Sjögren's syndrome at the crossroad of polyautoimmunity.

Abstract

The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases.

DOI: 10.1016/j.jaut.2012.05.008
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@article{AmadorPatarroyo2012SjgrensSA, title={Sj{\"{o}gren's syndrome at the crossroad of polyautoimmunity.}, author={Manuel J Amador-Patarroyo and Juan Guillermo Arbelaez and Ruben D Mantilla and Alberto Rodriguez-Rodriguez and Jorge C{\'a}rdenas-Rold{\'a}n and Ricardo Pineda-Tamayo and Mayra R Guarin and Liliana Lopez Kleine and Adriana Rojas-Villarraga and Juan-Manuel Anaya}, journal={Journal of autoimmunity}, year={2012}, volume={39 3}, pages={199-205} }