Sjögren's syndrome

@article{Fox2005SjgrensS,
  title={Sj{\"o}gren's syndrome},
  author={Robert Irving Fox},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={321-331}
}
  • R. Fox
  • Published 1 September 1995
  • Medicine, Biology
  • The Lancet

Figures from this paper

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In the absence of trials involving patients with primary Sjögren's syndrome, severe organ manifestations are treated with immunosuppressive agents (including prednisone, methotrexate, mycophenolate sodium, azathioprine, and cyclophosphamide), in accordance with guidelines for systemic lupus erythematosus and other connective‐tissue diseases.
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The genetic component of SS is discussed on the basis of three known observations: age at onset and sex-dependent presentation, familial clustering of the disease, and dissection of the genetic component.
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  • Medicine
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The present comprehensive review of primary Sjögren’s syndrome addresses the clinical manifestations and complications of the disease, the diagnostic workup, the pathogenic mechanisms and the therapeutic approaches.
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References

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Sjögren's syndrome: autoimmune epithelitis.
TLDR
Based on the sequential application of the validated European classification criteria for SS, a practical algorithm for diagnosis is presented and progress in the understanding of the broad clinicopathological spectrum of the entity remains largely empirical and symptomatic.
The genetics of primary Sjögren’s syndrome
TLDR
The authors review the human leukocyte antigen and non-human leukocytes antigen genetic associations herewith, knowing that new technologies are providing access to the entire genome for association studies.
Genetic Basis of Sjögren's Syndrome. How Strong is the Evidence?
TLDR
The genetic component of SS is discussed on the basis of three known observations: age at onset and sex-dependent presentation, familial clustering of the disease, and dissection of the genetic component.
Current issues in the diagnosis and treatment of Sjögren's syndrome.
TLDR
The proposed EEC modification will require either a positive minor salivary gland biopsy or a positive autoantibody against Sjögren's-associated A (Ro) or B (La) antigen, which will decrease the proportion of women fulfilling EEC criteria from 3-5% to about 0.5%, similar to San Diego and San Francisco criteria.
Sjögren's syndrome. Controversies and progress.
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Malignant lymphoma in primary Sjögren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome.
TLDR
The novel observations of this study were those related to the type of MNHL, the survival prognosis, and the very high frequency of skin vasculitis, peripheral nerve involvement, anemia, and lymphopenia.
Sjögren’s syndrome: current therapies remain inadequate for a common disease
  • R. Fox
  • Medicine
    Expert opinion on investigational drugs
  • 2000
TLDR
This review will concentrate on primary SS, a systematic autoimmune disease characterised by dysfunction of the lacrimal and salivary glands that has extra glandular organ involvement including lung, renal, peripheral and central nervous system manifestations, vasculitis of skin and other organs and increased frequency of lymphoma.
Cutaneous manifestations of primary Sjögren's syndrome are underestimated.
TLDR
An inventory of the possible skin complications of Sjogren's syndrome is drawn up, including xerosis and epidermal IgG deposits, which include vasculitis and cutaneous B cell lymphoma.
Recent advances in understanding molecular mechanisms in the pathogenesis and antibody profile of Sjögren’s syndrome
TLDR
The effects of adrenopause in Sjögren’s syndrome and on dehydroepiandrosterone and its intracrine metabolism in target tissues can influence the maintenance and remodeling of exocrine glands and may explain, in part, another important disease symptom—fatigue.
Collaborative research into outcome measures in Sjögren's syndrome
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    Scandinavian journal of rheumatology. Supplement
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TLDR
Clinical trials of new therapies in disorders such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have been advanced by the development of internationally agreed assessment and outcome measures such as the American College of Rheumatology/EULAR core datasets of disease activity in RA and measures of activity and damage in SLE.
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