Sjögren's syndrome (Sicca syndrome): current issues.

  title={Sj{\"o}gren's syndrome (Sicca syndrome): current issues.},
  author={H M Moutsopoulos and Thomas M. Chused and Dean L. Mann and John H Klippel and Anthony S. Fauci and Mike Frank and T. J. Lawley and Matthias Hamburger},
  journal={Annals of internal medicine},
  volume={92 2 Pt 1},
This paper outlines the clinical, serologic, and immunogenetic differences and similarities of Sjögren's syndrome alone (primary) and Sjögren's syndrome associated with rheumatoid arthritis and systemic lupus erythematosus (secondary). The immunoregulation in Sjögren's syndrome is discussed and the incidence of immune complex-like material, its nature, pathophysiology, and clearance by the Fc recptor of the reticuloendothelial system presented. 

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