Sjögren's syndrome: an update on epidemiology and current insights on pathophysiology.

@article{Reksten2014SjgrensSA,
  title={Sj{\"o}gren's syndrome: an update on epidemiology and current insights on pathophysiology.},
  author={Tove Ragna Reksten and Malin Viktoria Jonsson},
  journal={Oral and maxillofacial surgery clinics of North America},
  year={2014},
  volume={26 1},
  pages={1-12}
}
Primary Sjögren's syndrome (pSS) is an autoimmune chronic inflammatory disorder affecting 0.2% to 3.0% of the population, with a 9:1 female to male ratio. Features are oral and ocular dryness, local and systemic autoantibody production, and progressive focal mononuclear cell infiltration in the affected salivary and lacrimal glands. Lymphoma is the most severe complication of pSS, occurring in 4% to 5% of patients. Genetic studies identified an association with HLA and susceptibility genes in… CONTINUE READING