Sizing nanomatter in biological fluids by fluorescence single particle tracking.

@article{Braeckmans2010SizingNI,
  title={Sizing nanomatter in biological fluids by fluorescence single particle tracking.},
  author={Kevin Braeckmans and Kevin Buyens and Wim Bouquet and Chris Vervaet and Philippe Joye and F. Waldorp de Vos and Laurent Plawinski and Lo{\"i}c Doeuvre and Eduardo {\'A}ngles-Cano and Niek N Sanders and J. J. Demeester and Stefaan C. De Smedt},
  journal={Nano letters},
  year={2010},
  volume={10 11},
  pages={4435-42}
}
Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle tracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood… CONTINUE READING
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