Size of the transmembrane channels produced by complement proteins C5b-8.

@article{Ramm1982SizeOT,
  title={Size of the transmembrane channels produced by complement proteins C5b-8.},
  author={L E Ramm and M B Whitlow and Manfred M. Mayer},
  journal={Journal of immunology},
  year={1982},
  volume={129 3},
  pages={1143-6}
}
It has been shown previously that erythrocytes can be lysed by complement proteins C5b-8, albeit at a much lower rate than C5b-9. We have now performed kinetic sieving experiments with resealed erythrocyte ghosts using sucrose (0.9 nm molecular diameter) and inulin (3.0 nm molecular diameter) as markers. We found that treatment of the ghosts with C5b-8 released sucrose, but not inulin. Addition of C9 to ghosts carrying C5b-8 dramatically increased the rate of sucrose flux and, in addition… CONTINUE READING
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