Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1.

@article{Kim2000SizeLO,
  title={Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1.},
  author={Y M Kim and Daniel M. Ziegler},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 8},
  pages={1003-6}
}
Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. However, there was no detectable activity with 1,3-diphenylthiourea or larger thiocarbamides. Microsomes from control Sf9 cells were devoid of methimazole or thiourea S-oxygenase activity. Trimethylamine up to 1.0 mM had no detectable effect on the oxidation of… CONTINUE READING
19 Extracted Citations
10 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 19 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 10 references

Nature of the 4 a - flavin hydroperoxide of microsomal flavin - containing monooxygenase

  • KC Jones
  • 1985
1 Excerpt

Nature of the 4a-flavin hydroperoxide of microsomal flavin-containing monooxygenase. Doctoral Dissertation in Biological Chemistry, University microfilms Int. no. DA8520922

  • KC Jones
  • 1985
2 Excerpts

Similar Papers

Loading similar papers…