Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells.

@article{Setzer1980SizeHI,
  title={Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells.},
  author={David R. Setzer and Michael McGrogan and Jack H. Nunberg and Robert T. Schimke},
  journal={Cell},
  year={1980},
  volume={22 2 Pt 2},
  pages={361-70}
}
We have examined in detail the RNA coding for dihydrofolate reductase (DHFR) in methotrexate-resistant mouse cells. We find four distinct DHFR messengers, ranging in size from 750 to 1600 nucleotides. All four are polyadenylated and polysomal and can be translated in vitro to produce a 21,000 dalton protein co-migrating with purified dihydrofolate reductase on SDS polyacrylamide gels. The major difference in these RNAs is the length of 3' untranslated regions, varying from about 80 nucleotides… CONTINUE READING
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