Size does matter: overcoming the adeno-associated virus packaging limit

@article{Flotte2000SizeDM,
  title={Size does matter: overcoming the adeno-associated virus packaging limit},
  author={Terence R. Flotte},
  journal={Respiratory Research},
  year={2000},
  volume={1},
  pages={16 - 18}
}
Recombinant adeno-associated virus (rAAV) vectors mediate long-term gene transfer without any known toxicity. The primary limitation of rAAV has been the small size of the virion (20 nm), which only permits the packaging of 4.7 kilobases (kb) of exogenous DNA, including the promoter, the polyadenylation signal and any other enhancer elements that might be desired. Two recent reports (D Duan et al: Nat Med 2000, 6:595-598; Z Yan et al: Proc Natl Acad Sci USA 2000, 97:6716-6721) have exploited a… CONTINUE READING

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