Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors.

@article{Fifis2004SizedependentIT,
  title={Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors.},
  author={Theodora Fifis and Anita Gamvrellis and Blessing Crimeen-Irwin and Geoffrey A. Pietersz and Jie Li and Patricia L. Mottram and Ian F.C. Mckenzie and Magdalena Plebanski},
  journal={Journal of immunology},
  year={2004},
  volume={173 5},
  pages={
          3148-54
        }
}
Infection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In this study, we present a new vaccine design, with Ag covalently conjugated to solid core nano-beads of narrowly defined size (0.04-0.05 microm) that localize to dendritic cells (DEC205(+) CD40(+), CD86(+)) in draining lymph nodes, inducing high levels of IFN-gamma production (CD8 T cells: precursor frequencies 1/5000 to 1/1000) and high… CONTINUE READING
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