Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield

@article{Ding2001SizedependentCO,
  title={Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield},
  author={Zhongli Ding and Robin B. Fong and Cynthia J. Long and Patrick S. Stayton and Allan S. Hoffman},
  journal={Nature},
  year={2001},
  volume={411},
  pages={59-62}
}
Many medical and biotechnological processes rely on controlling and manipulating the molecular-recognition capabilities of proteins. This can be achieved using small molecules capable of competing for protein binding or by changing environmental parameters that affect protein structure and hence binding. An alternative is provided by stimuli-responsive polymers that change reversibly from a water-soluble expanded coil to a water-insoluble collapsed globule upon small changes in temperature, pH… CONTINUE READING
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