Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting.

@article{Donovan2014SizecontrolledSO,
  title={Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting.},
  author={Alexander J. Donovan and Joseph Kalkowski and Stephanie A Smith and James H Morrissey and Ying Liu},
  journal={Biomacromolecules},
  year={2014},
  volume={15 11},
  pages={
          3976-84
        }
}
Size-controlled granular polyphosphate (PolyP) nanoparticles were synthesized by precipitation in aqueous solutions containing physiological concentrations of calcium and magnesium. We demonstrate using dynamic light scattering (DLS) that the solubility is correlated inversely with PolyP chain length, with very long chain PolyP (PolyP1000+, more than 1000 repeating units) normally found in prokaryotes precipitating much more robustly than shorter chains like those found in human platelet dense… CONTINUE READING

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