Size bias of fragile X premutation alleles in late-onset movement disorders.

@article{Jacquemont2006SizeBO,
  title={Size bias of fragile X premutation alleles in late-onset movement disorders.},
  author={S{\'e}bastien Jacquemont and Maureen A. Leehey and Randi J. Hagerman and Laurel A Beckett and Paul J. Hagerman},
  journal={Journal of medical genetics},
  year={2006},
  volume={43 10},
  pages={804-9}
}
BACKGROUND Fragile X-associated tremor/ataxia syndrome (FXTAS), caused by premutation expansions (55-200 CGG repeats) of the FMR1 gene, shares clinical features with other movement disorders, particularly in the domains of gait ataxia, intention tremor and parkinsonism. However, the prevalence of FXTAS within other diagnostic categories is not well defined. METHODS A meta-analysis was conducted of all published (n = 14) genetic screens for expanded FMR1 alleles to assess the prevalence and… CONTINUE READING

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