Size-based microfluidic multimodal microparticle sorter.
@article{Wang2015SizebasedMM,
title={Size-based microfluidic multimodal microparticle sorter.},
author={Xiao Wang and Ian Papautsky},
journal={Lab on a chip},
year={2015},
volume={15 5},
pages={
1350-9
}
}Microfluidic sorting of synthetic and biological microparticles has attracted much interest in recent years. Inertial microfluidics uses hydrodynamic forces to manipulate migration of such microparticles in microfluidic channels to achieve passive sorting based on size with high throughput. However, most inertial microfluidic devices are only capable of bimodal separation with a single cutoff diameter and a well-defined size difference. These limitations inhibit efficient separation of real…
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References
SHOWING 1-10 OF 72 REFERENCES
Modulation of aspect ratio for complete separation in an inertial microfluidic channel.
- BiologyLab on a chip
- 2013
A simple inertial microfluidic system with high efficiency and purity, built on the concept of two-stage inertial migration which permits precise prediction of particle or cell position within the microchannel is reported.
Vortex-aided inertial microfluidic device for continuous particle separation with high size-selectivity, efficiency, and purity.
- BiologyBiomicrofluidics
- 2013
An inertial microfluidic device with simple geometry for continuous extraction of large particles with high size-selectivity, high efficiency, and high purity, with broad applications in cell separations is reported.
Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel
- ChemistryScientific reports
- 2014
The results indicate that the proposed device has an integrative advantage to the existing microfluidic separation techniques, taking accounts of purity, efficiency, parallelizability, footprint, throughput and resolution.
Continuous particle separation in spiral microchannels using Dean flows and differential migration.
- EngineeringLab on a chip
- 2008
A passive microfluidic device with spiral microchannel geometry for complete separation of particles that takes advantage of the dual role of Dean forces for focusing larger particles in a single equilibrium position and transposing the smaller particles from the inner half to the outer half of the microchannel cross-section.
Continuous separation of blood cells in spiral microfluidic devices.
- Engineering, BiologyBiomicrofluidics
- 2013
Improved Archimedean spiral devices to achieve cell separation in less than 8 cm of downstream focusing length are reported, which offer a path towards possible development of a lab-on-chip for point-of-care blood analysis with high efficiency, low cost, and reduced analysis time.
Enhanced size-dependent trapping of particles using microvortices
- BiologyMicrofluidics and nanofluidics
- 2013
The insights gained from the systematic investigation suggest optimization solutions that enhance device performance (efficiency, size selectivity, and yield) and are applicable to selective isolation and trapping of large rare cells as well as other applications.
Microfluidics for cell separation
- ChemistryMedical & Biological Engineering & Computing
- 2010
This review describes the current state-of-the-art in microfluidics-based cell separation techniques, and common separation metrics, including separation markers, resolution, efficiency, and throughput, of these techniques are discussed.
Inertial microfluidics for sheath-less high-throughput flow cytometry
- BiologyBiomedical microdevices
- 2010
This paper describes a sheath-less, on-chip flow cytometry system based on the principle of Dean coupled inertial microfluidics, which relies entirely on the microchannel geometry for particle focusing, eliminating the need for complex microchannel designs and additionalmicrofluidic plumbing associated with she Heath-based techniques.
Combined microfluidic-micromagnetic separation of living cells in continuous flow
- EngineeringBiomedical microdevices
- 2006
This paper describes a miniaturized, integrated, microfluidic device that can pull molecules and living cells bound to magnetic particles from one laminar flow path to another by applying a local…
Free flow acoustophoresis: microfluidic-based mode of particle and cell separation.
- EngineeringAnalytical chemistry
- 2007
The results show that free flow acoustophoresis can be used to perform complex separation tasks, thereby offering an alternative to expensive and time-consuming methods currently in use.





