Size and charge selectivity of the glomerular filter in early experimental diabetes in rats.

@article{Rippe2007SizeAC,
  title={Size and charge selectivity of the glomerular filter in early experimental diabetes in rats.},
  author={Catarina Rippe and Anna Rippe and Ole Torffvit and Bengt Rippe},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 5},
  pages={F1533-8}
}
Microalbuminuria is an early sign of diabetic nephropathy. The aim of the present study was to investigate whether the changes of the glomerular filtration barrier in early experimental diabetes are due to size- or charge-selective alterations. Wistar rats, made diabetic by streptozotocin (STZ) and having their blood glucose maintained at approximately 20 mM for 3 or 9 wk, were compared with age-matched controls. Glomerular clearances of native albumin (Cl-HSA) and neutralized albumin (Cl-nHSA… CONTINUE READING