Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release

@inproceedings{Galice2018SizeMR,
  title={Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release},
  author={Samuel Galice and Y Xie and Yongkai Yang and Daisuke Sato and Donald M. Bers},
  booktitle={Journal of the American Heart Association},
  year={2018}
}
BACKGROUND Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+) release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes, RyRs are found in clusters of various sizes and shapes, and RyR cluster size may critically influence normal and arrhythmogenic Ca2+ spark and wave formation. However, the actual RyR cluster sizes at specific Ca2+ spark sites have never been measured in the physiological setting. METHODS AND RESULTS Here we measured RyR cluster… CONTINUE READING
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