Sixteen Years of Meiotic Silencing by Unpaired DNA.

@article{Hammond2017SixteenYO,
  title={Sixteen Years of Meiotic Silencing by Unpaired DNA.},
  author={Thomas M. Hammond},
  journal={Advances in genetics},
  year={2017},
  volume={97},
  pages={1-42}
}
The filamentous fungus Neurospora crassa possesses a process called meiotic silencing by unpaired DNA (MSUD). MSUD has a remarkable ability to scan homologous chromosomes for unpaired DNA during meiosis. After unpaired DNA is identified, MSUD silences all RNA from the unpaired DNA along with any RNA transcribed from homologous sequences at other locations in the genome, regardless of their pairing state. The mechanism by which unpaired DNA is detected is unknown. Unpaired DNA segments can be as… CONTINUE READING
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