Six3 and Six6 activity is modulated by members of the groucho family.

@article{LpezRos2003Six3AS,
  title={Six3 and Six6 activity is modulated by members of the groucho family.},
  author={Javier L{\'o}pez-R{\'i}os and Kristin Tessmar and Felix Loosli and Joachim Wittbrodt and Paola Bovolenta},
  journal={Development},
  year={2003},
  volume={130 1},
  pages={185-95}
}
Six3 and Six6 are two genes required for the specification and proliferation of the eye field in vertebrate embryos, suggesting that they might be the functional counterparts of the Drosophila gene sine oculis (so). Phylogenetic and functional analysis have however challenged this idea, raising the possibility that the molecular network in which Six3 and Six6 act may be different from that described for SO. To address this, we have performed yeast two-hybrid screens, using either Six3 or Six6… CONTINUE READING
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