Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population

@article{Yasukochi2018SixNS,
  title={Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population},
  author={Yoshiki Yasukochi and Jun Sakuma and Ichiro Takeuchi and Kimihiko Kato and Mitsutoshi Oguri and Tetsuo Fujimaki and Hideki Horibe and Yoshiji Yamada},
  journal={Biomedical Reports},
  year={2018},
  volume={9},
  pages={123 - 134}
}
Coronary artery disease (CAD) and cerebral infarction (CI) remain major causes of morbidity and mortality in humans. Recent genome-wide association studies have identified various genetic variants associated with these diseases. However, these studies were commonly conducted in a cross-sectional manner. Therefore, the present research performed longitudinal exome-wide association studies for CAD and CI using data on ~244,000 genotyped variants and the clinical data of 6,026 Japanese individuals… 

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