Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  title={Six new loci associated with body mass index highlight a neuronal influence on body weight regulation},
  author={Cristen J. Willer and Elizabeth K. Speliotes and Ruth J. F. Loos and Shengxu Li and Cecilia M. Lindgren and Iris M. Heid and Sonja I. Berndt and Amanda Elliott and Anne U. Jackson and Claudia Lamina and Guillaume Lettre and Noha Lim and Helen Lyon and Steven Mccarroll and Konstantinos Papadakis and Lu Qi and Joshua C. Randall and Rosa Maria Roccasecca and Serena Sanna and Paul Scheet and Michael N. Weedon and Eleanor Wheeler and Jing Hua Zhao and Leonie C. Jacobs and Inga Prokopenko and Nicole Soranzo and Toshiko Tanaka and Nicholas John Timpson and Peter Almgren and Amanda Bennett and Richard N. Bergman and Sheila Anne Bingham and Lori L Bonnycastle and Morris J. Brown and Noël P. Burtt and Peter S. Chines and Lachlan J. Coin and Francis S. Collins and John M. Connell and Cyrus Cooper and George Davey Smith and Elaine M. Dennison and Parimal A. Deodhar and Paul Elliott and Michael R. Erdos and Karol Estrada and David M. Evans and Lauren Gianniny and Christian Gieger and Christopher J Gillson and Candace Guiducci and Rachel Hackett and David Hadley and Alistair S. Hall and Aki Samuli Havulinna and Johannes Hebebrand and Albert Hofman and Bo Isomaa and Kevin B. Jacobs and Toby Johnson and Pekka Jousilahti and Zorica Jovanovic and Kay-Tee Khaw and Peter Kraft and Mikko Kuokkanen and Johanna Kuusisto and Jaana Laitinen and Edward G. Lakatta and Jian’an Luan and Robert N. Luben and Massimo Mangino and Wendy L McArdle and Thomas Meitinger and Antonella Mulas and Patricia B. Munroe and Narisu Narisu and Andy Ness and Kate Northstone and Stephen O’Rahilly and Carolin Purmann and Matthew G. Rees and Martin Ridderstr{\aa}le and Susan M. Ring and Fernando Rivadeneira and Aimo O Ruokonen and Manjinder S. Sandhu and Jouko Saramies and Laura J. Scott and Angelo Scuteri and Kaisa Silander and Matthew A Sims and Kijoung Song and Jonathan Stephens and Suzanne E Stevens and Heather M. Stringham and Y. C. Loraine Tung and Timo T. Valle and Cornelia M. van Duijn and Karani Santhanakrishnan Vimaleswaran and Peter Vollenweider and G{\'e}rard Waeber and Chris Wallace and Richard M Watanabe and Dawn M. Waterworth and Nicholas Watkins and Jacqueline C. M. Witteman and Eleftheria Zeggini and Guangju Zhai and M. Carola Zillikens and David M Altshuler and Mark J. Caulfield and Stephen J. Chanock and I Sadaf Farooqi and Luigi Ferrucci and Jack M. Guralnik and Andrew T. Hattersley and Frank B. Hu and Marjo-Riitta Jarvelin and Markku Laakso and Vincent Mooser and Ken K. Ong and Willem Hendrik Ouwehand and Veikko V Salomaa and Nilesh J. Samani and Tim D. Spector and Tiinamaija Tuomi and Jaakko Tuomilehto and Manuela Uda and Andr{\'e} G. Uitterlinden and Nicholas J. Wareham and Panagiotis Deloukas and Timothy M. Frayling and Leif C. Groop and Richard B. Hayes and David J. Hunter and Karen L. Mohlke and Leena Peltonen and David Schlessinger and David P. Strachan and Heinz-Erich Wichmann and Mark I. McCarthy and Michael Boehnke and In{\^e}s Barroso and Gonçalo R. Abecasis and Joel N. Hirschhorn},
  journal={Nature Genetics},
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 × 10−8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant… 

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