Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.

@article{Romanos2009SixNC,
  title={Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.},
  author={Jihane Romanos and Donatella Barisani and Gosia Trynka and Alexandra Zhernakova and Maria Teresa Bardella and Cisca Wijmenga},
  journal={Journal of medical genetics},
  year={2009},
  volume={46 1},
  pages={60-3}
}
BACKGROUND AND AIMS The first genome wide association study on coeliac disease (CD) and its follow-up have identified eight new loci that contribute significantly towards CD risk. Seven of these loci contain genes controlling adaptive immune responses, including IL2/IL21 (4q27), RGS1 (1q31), IL18RAP (2q11-2q12), CCR3 (3p21), IL12A (3q25-3q26), TAGAP (6q25) and SH2B3 (12q24). METHODS We selected the nine most associated single nucleotide polymorphisms to tag the eight new loci in an Italian… CONTINUE READING

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