Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease.

  title={Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease.},
  author={Larry Baum and Christopher Wai-kei Lam and Stanley Kwok-Kuen Cheung and Timothy C.Y. Kwok and Victor Wing Cheong Lui and Joshua Tsoh and Linda CW Lam and Vivian Yee-fong Leung and Elsie Hui and Chelsia Ng and Jean Woo and Helen Fung Kum Chiu and William B Goggins and Benny Chung Ying Zee and King-fai Cheng and Carmen Yuet Shim Fong and Adrian Wong and Hazel Mok and Moses Sing Sum Chow and Ping C. Ho and Siu-Po Ip and Chung Shun Ho and Xiongwen Yu and Caroline Yau Lin Lai and Ming-Houng Chan and Samuel S L Szeto and Iris Hiu Shuen Chan and Vincent Chung-Tong Mok},
  journal={Journal of clinical psychopharmacology},
  volume={28 1},
  • L. BaumC. Lam V. Mok
  • Published 1 February 2008
  • Biology
  • Journal of clinical psychopharmacology
To the Editors:Curcumin is a polyphenolic molecule that comprises approximately 5% of turmeric, giving the spice its color but not flavor. It is used in processed foods as a yellow coloring. 1 Because of its anti-inflammatory and antioxidant properties, curcumin has been tested in animal models of A 

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

Curcumin was generally well-tolerated although three subjects on curcumin withdrew due to gastrointestinal symptoms, and preliminary data suggest limited bioavailability of this compound.

Randomized, placebo controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in moderate to severe asthmatics

This study will seek to better understand if curcumin can be used as an adjunctive therapy for improving asthma control of patients with moderate to severe asthma; a finding it hope will allow for a more affordable treatment.

The protective effects of polyphenols on Alzheimer's disease: A systematic review

Curcumin as an Add-On to Antidepressive Treatment: A Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Study

Although there is no definitive proof that curcumin can induce an earlier beneficial effect of antidepressive agents, it seems like an extended study is needed to prove it, using higher therapeutic doses ofCurcumin.

Effects of Curcumin on Cognitive Function—A Systematic Review of Randomized Controlled Trials

Before curcumin can be recommended to treat or reduce rates of cognitive decline, well-designed trials with standardization in dose, method of assessing cognition, and duration are required to determine the most bioavailable form ofCurcumin with minimal adverse effects.

The impact of curcumin and its modified formulations on Alzheimer's disease

The effects of curcumin and its modified formulations in human and experimental models of AD are gathered to gather the effects of the main ingredient of turmeric traditionally used in Asian medicine.

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

Curcumin is not safe since it initiates several toxic effects including diarrhea, iron-deficient anemia, potential harmful interactions with drug-metabolizing enzymes, and DNA damage, which could be even more severe in elderly individuals such as those suffering from AD.

The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

The curcumin group had a significantly higher risk of gastrointestinal AEs than the placebo group and no significant difference existed in the domains of language, episodic memory/visual learning, verbal memory, cognitive flexibility/problem solving, and overall cognitive function.

Premium CurcuMIND Curcumin Optimized with Vitamin D for Cognitive Support Synergistic combination of curcumin and vitamin

  • Psychology, Biology
  • 2018
One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo, and a significant acute-on-chronic treatment effect on alertness and contentedness was also observed.



Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo‐controlled double‐blind study

There is no evidence of relevant differences in the efficacy of EGb 761 and donepezil in the treatment of mild to moderate Alzheimer's dementia, so the use of both substances can be justified.

Escitalopram 10 mg/day is effective and well tolerated in a placebo-controlled study in depression in primary care.

Escitalopram 10 mg/day had a statistically significantly better antidepressant effect than placebo as early as week 1, and was safe and very well tolerated with a low overall withdrawal rate similar to that for placebo.

Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients.

Escitalopram, a single isomer SSRI, is well-tolerated and has demonstrated antidepressant efficacy at a dose of 10 mg/day.

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1β, a proinflammatory cytokine elevated in the brains of these mice, and shows promise for the prevention of Alzheimer's disease.

Curry consumption and cognitive function in the elderly.

Tentative evidence of better cognitive performance from curry consumption in nondemented elderly Asians is reported, which should be confirmed in future studies.

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.

Curcumin might exert a net protective effect against Abeta toxicity or might suppress inflammatory damage by preventing metal induction of NF-kappaB.

Biological activities of Curcuma longa L.

An overview of the pharmacological activities of C. longa L., showing its importance, and experiments showing the anti-parasitic, anti-inflammatory potency of curcumin and extracts of this plant by parenteral and oral application in animal models.

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease

Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease.

Measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD.