Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF−308A in systemic lupus erythematosus

@article{Linden2001SixMM,
  title={Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF−308A in systemic lupus erythematosus},
  author={MW van der Linden and AR van der Slik and Eric Zanelli and M. J. Giphart and E Pieterman and GM T h Schreuder and R G J Westendorp and Twj Huizinga},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={373-380}
}
Differences in allelic distribution at loci surrounding the human HLA-DRB1 and tumor necrosis factor (TNF) genes have been observed in association with systemic lupus erythematosus (SLE). We investigated whether the association of HLA-DRB1*0301 (HLA-DR3) and TNF−308A with SLE could be attributed to polymorphic markers in the chromosomal region encompassed by HLA-DRB1 and HLA-C. Ninety-one consecutive Caucasian patients with SLE and 253 controls (organ donors) were typed for HLA-DRB1… CONTINUE READING

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