Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

@article{Engelkamp1993SixSG,
  title={Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.},
  author={Dieter Engelkamp and Beat W. Sch{\"a}fer and M. G. Matt{\'e}i and P. Erne and Claus Wilhelm Heizmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6547-51}
}
The human genome contains large regions that are highly structured. Sequence-related members of multigene families are often found in a clustered organization. Here we describe a previously unrecognized gene cluster composed of genes coding for calcium-binding proteins of the S100 family. The linkage of six S100 genes was established by pulsed-field gel electrophoresis, and a contiguous DNA sequence of 15 kilobases containing the full coding region of four different S100 genes was characterized… CONTINUE READING

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