Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial.

@article{Couturaud2015SixMV,
  title={Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial.},
  author={Francis Couturaud and Olivier Sanchez and Gilles Pernod and Patrick Mismetti and Patrick J{\'e}go and Elisabeth Duhamel and Karine Provost and Claire Bal dit Sollier and Emilie Presles and Philippe Castellant and Florence Parent and P. -Y. Salaun and Luc Bressollette and Michel Nonent and Philippe Lorillon and Philippe Girard and Karine Lacut and Marie Gu{\'e}gan and Jean-Luc Bosson and Silvy Laporte and Christophe Leroyer and Herv{\'e} D{\'e}cousus and Guy Meyer and Dominique Mottier},
  journal={JAMA},
  year={2015},
  volume={314 1},
  pages={31-40}
}
IMPORTANCE The optimal duration of anticoagulation after a first episode of unprovoked pulmonary embolism is uncertain. OBJECTIVES To determine the benefits and harms of an additional 18-month treatment with warfarin vs placebo, after an initial 6-month nonrandomized treatment period on a vitamin K antagonist. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind trial (treatment period, 18 months; median follow-up, 24 months); 371 adult patients who had experienced a first episode of… CONTINUE READING
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