Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.

  title={Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.},
  author={Cyril David Mazer and Richard Paul Whitlock and Dean A. Fergusson and Emilie P Belley-C{\^o}t{\'e} and Katherine Ann Connolly and Boris Khanykin and Alexander John Gregory and {\'E}tienne de M{\'e}dicis and François Martin Carrier and Shay McGuinness and Paul J Young and Kelly Byrne and Juan Carlos Villar and Alistair Royse and Hilary P. Grocott and Manfred Daniel Seeberger and Chirag Mukesh Mehta and Francois Lellouche and Gregory M. T. Hare and Thomas W Painter and Stephen E. Fremes and Summer Syed and Sean M Bagshaw and Nian-Chih Hwang and Colin Forbes Royse and Judge Jean Graham Hall and David Dai and Nikhil Mistry and Kevin E. Thorpe and Subodh Verma and Peter J{\"u}ni and Nadine Shehata},
  journal={The New England journal of medicine},
  volume={379 13},
BACKGROUND We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure with dialysis by hospital discharge or 28 days after surgery, whichever came first. We now report the clinical outcomes at 6 months after surgery. METHODS We randomly assigned… CONTINUE READING
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Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2018

Transfusion triggers in cardiac surgery: Where do we go from here?

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