Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.

@article{Py2004Siva1AA,
  title={Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.},
  author={B{\'e}n{\'e}dicte Py and Christian Slomianny and Patrick Auberger and Patrice Xavier Petit and Serge B{\'e}nichou},
  journal={Journal of immunology},
  year={2004},
  volume={172 7},
  pages={4008-17}
}
Siva-1 is a death domain-containing proapoptotic protein identified as an intracellular ligand of CD27 and of the glucocorticoid-induced TNFR family-related gene, which are two members of the TNFR family expressed on lymphoid cells. Although Siva-1 expression is up-regulated in multiple pathological processes, little is known about the signaling pathway underlying the Siva-induced apoptosis. In this study, we investigated the mechanism of the proapoptotic activity of Siva-1 and an alternative… CONTINUE READING

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