Sites of steroid production in ovine graafian follicles in culture.


The follicular components responsible for the synthesis of oestrogen, testosterone, and progesterone have been localized by studying in vitro the steroidogenic capacity of (1) intact follicles, (2) opened but undisturbed follicle walls, (3) isolated thecal shells, (4) granulosa cells and (5) co-cultures of thecal shells and granulosa monolayers. Oestrogen… (More)