Sites of antinatriuretic action of insulin along rat nephron.

@article{Fraille1992SitesOA,
  title={Sites of antinatriuretic action of insulin along rat nephron.},
  author={E. F{\'e}raille and Sophie Marsy and Lydie Cheval and C. Barlet-Bas and C. Khadouri and Herv{\'e} Favre and Alain Doucet},
  journal={The American journal of physiology},
  year={1992},
  volume={263 1 Pt 2},
  pages={F175-9}
}
This study was aimed at identifying the renal sites of the antinatriuretic action of insulin by evaluating whether this hormone may alter the function of Na-K-ATPase in specific nephron segments. For this purpose, possible actions of insulin on the rate of 86Rb uptake were evaluated in vitro on single segments of proximal convoluted tubule (PCT), thick ascending limb, and collecting tubule microdissected from collagenase-treated kidneys of normal rats. Results indicate that physiological… CONTINUE READING

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