Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

  title={Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors},
  author={S. Mihic and Q. Ye and M. Wick and V. V. Koltchine and M. D. Krasowski and S. E. Finn and M. P. Mascia and C. F. Valenzuela and K. Hanson and E. Greenblatt and R. Harris and N. Harrison},
  • S. Mihic, Q. Ye, +9 authors N. Harrison
  • Published 1997
  • Chemistry, Medicine
  • Nature
  • Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as γ-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of inhaled anaesthetics. The function of GABAA and glycine receptors is enhanced by a number of anaesthetics and alcohols, whereas activity of the related GABA ρ1 receptor is reduced. We… CONTINUE READING
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