Sites of adenosine formation, action and inactivation in the brain.

@article{Meghji1990SitesOA,
  title={Sites of adenosine formation, action and inactivation in the brain.},
  author={P Meghji and Andrew C Newby},
  journal={Neurochemistry international},
  year={1990},
  volume={16 3},
  pages={227-32}
}
Two extreme and non-exclusive hypotheses can be put forward to account for the largely inhibitory actions of adenosine on neural activity. Adenosine formation may be linked to the balance between formation and degradation of cytoplasmic ATP and hence only be indirectly related to neurotransmission. Adenosine formed by this route must then diffuse out of the cell to reach extracellular receptor sites. It may then act on the adenosine forming cells, neighbouring neurones or other cells including… CONTINUE READING