Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.

@article{ZernikKobak1997SitesOU,
  title={Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.},
  author={M Zernik-Kobak and Kersi Vasunia and Michele Connelly and Carl W. Anderson and Kathleen Dixon},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 38},
  pages={23896-904}
}
Exposure of mammalian cells to UV radiation alters gene expression and cell cycle progression; some of these responses may ensure survival or serve as mutation-avoidance mechanisms, lessening the consequences of UV-induced DNA damage. We showed previously that UV irradiation increases phosphorylation of the p34 subunit of human replication protein A (RPA) and that this hyperphosphorylation correlated with loss of activity of the DNA replication complex. To characterize further the role of RPA… CONTINUE READING

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