Sites in simian virus 40 chromatin which are preferentially cleaved by endonucleases

@article{Scott1978SitesIS,
  title={Sites in simian virus 40 chromatin which are preferentially cleaved by endonucleases},
  author={W. Scott and D. Wigmore},
  journal={Cell},
  year={1978},
  volume={15},
  pages={1511-1518}
}
  • W. Scott, D. Wigmore
  • Published 1978
  • Biology, Medicine
  • Cell
  • Abstract Simian virus 40 (SV40) chromatin isolated from infected BSC-1 cell nuclei was incubated with deoxyribonuclease I, staphylococcal nuclease or an endonuclease endogenous to BSC-1 cells under conditions selected to introduce one doublestrand break into the viral DNA. Full-length linear DNA was isolated, and the distribution of sites of initial cleavage by each endonuclease was determined by restriction enzyme mapping. Initial cleavage of SV40 chromatin by deoxyribonuclease I or by… CONTINUE READING
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