Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.

@article{Silva2011SitesAR,
  title={Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.},
  author={Laurie A. Silva and Blair L Strang and Eric W. Lin and Jeremy P Kamil and Donald M Coen},
  journal={Virology},
  year={2011},
  volume={417 2},
  pages={268-80}
}
The human cytomegalovirus DNA polymerase subunit UL44 is a phosphoprotein, but its sites and roles of phosphorylation have not been investigated. We compared sites of phosphorylation of UL44 in vitro by the viral protein kinase UL97 and cyclin-dependent kinase 1 with those in infected cells. Transient treatment of infected cells with a UL97 inhibitor greatly reduced labeling of two minor UL44 phosphopeptides. Viruses containing alanine substitutions of most UL44 residues that are phosphorylated… CONTINUE READING

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