Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

@article{Herrero1997SitesAM,
  title={Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon},
  author={A. Herrero and G. Barja},
  journal={Mechanisms of Ageing and Development},
  year={1997},
  volume={98},
  pages={95-111}
}
Basal (substrate alone) and maximum rates of H2O2 production, oxygen consumption and free radical leak in the respiratory chain were higher in heart mitochondria of the short-lived rat (4 years) than in the long-lived pigeon (35 years). This suggests that the low free radical production of pigeon heart mitochondria is due in part to both a low electron flow and a low percent leak of electrons out of sequence in the respiratory chain. Thenoyltrifluoroacetone did not increase H2O2 production with… Expand
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