Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C.

@article{Vanni2009SitesAM,
  title={Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C.},
  author={Ester Vanni and Maria Lorena Abate and Elena Gentilcore and Ingrid Hickman and Roberto Gambino and Maurizio Cassader and Antonina Smedile and Ele Ferrannini and Mario Rizzetto and Giulio Marchesini and Amalia Gastaldelli and Elisabetta Bugianesi},
  journal={Hepatology},
  year={2009},
  volume={50 3},
  pages={697-706}
}
UNLABELLED Chronic hepatitis C (CHC) has been associated with type 2 diabetes and insulin resistance, but the extent of impairment in insulin action, the target pathways involved, and the role of the virus per se have not been defined. In this study, we performed a euglycemic hyperinsulinemic clamp (1 mU x minute(-1) x kg(-1)) coupled with infusion of tracers ([6,6-(2)H(2)]glucose, [(2)H(5)]glycerol) and indirect calorimetry in 14 patients with biopsy-proven CHC, who were selected not to have… CONTINUE READING
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