Sites and mechanisms for nicotine's action in the brain.

  title={Sites and mechanisms for nicotine's action in the brain.},
  author={Leo G. Abood and D T Reynolds and Helen Booth and Jean M Bidlack},
  journal={Neuroscience and biobehavioral reviews},
  volume={5 4},
A variety of pharmacologic, behavioral, and receptor-binding studies were performed in an effort to determine the mechanism and site of action of nicotine on the rat brain. When nicotine was given into the lateral or fourth ventricles or directly into the lateral vestibular nuclei of rats, it produced a characteristic prostration often accompanied by tonic seizures and body rotation along a longitudinal axis. Of a variety of brain areas studied, the prostration response could only be elicited… CONTINUE READING


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