Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays.

@article{Thein2011SitespecificSO,
  title={Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays.},
  author={Myo Thein and An Cheng and Payal Khanna and Chun-Feng Zhang and Eun-Joo Park and Daniel Ahmed and Christopher J Goodrich and Fareid Asphahani and Fengbing Wu and Nadine Smith and Cheng Dong and Xiaoning Jiang and Miqin Zhang and Jian Xu},
  journal={Biosensors & bioelectronics},
  year={2011},
  volume={27 1},
  pages={25-33}
}
We developed a new instrumental method by which human melanoma cells (LU1205) are sonoporated via radiation pressures exerted by highly-confined ultrasonic waves produced by high lateral-resolution ultrasonic micro-transducer arrays (UMTAs). The method enables cellular-level site-specific sonoporation within the cell monolayer due to UMTAs and can be applicable in the delivery of drugs and gene products in cellular assays. In this method, cells are seeded on the biochip that employs UMTAs for… CONTINUE READING
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