Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations


BACKGROUND Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor mtDNA mutations. METHODS To test our hypothesis, we… (More)
DOI: 10.1186/s13046-017-0638-6

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