Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations

Abstract

BACKGROUND Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenesis. Therefore, we hypothesized that site-specific selection may influence tumor mtDNA mutations. METHODS To test our hypothesis, we… (More)
DOI: 10.1186/s13046-017-0638-6

7 Figures and Tables

Topics

  • Presentations referencing similar topics