Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars.

@article{Benes2009SitespecificRO,
  title={Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars.},
  author={Francine Mary Benes and Benjamin W. H. Lim and Sivan Subburaju},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 28},
  pages={11731-6}
}
GABA cell dysfunction in both schizophrenia (SZ) and bipolar disorder (BD) involves decreased GAD(67) expression, although this change involves fundamentally different networks of genes in the 2 disorders. One gene that is common to these 2 networks is cyclin D2, a key component of cell cycle regulation that shows increased expression in SZ, but decreased expression in BD. Because of the importance of cell cycle regulation in maintaining functional differentiation and DNA repair, the current… CONTINUE READING

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