Site-specific protein transamination using N-methylpyridinium-4-carboxaldehyde.

Abstract

The controlled attachment of synthetic groups to proteins is important for a number of fields, including therapeutics, where antibody-drug conjugates are an emerging area of biologic medicines. We have previously reported a site-specific protein modification method using a transamination reaction that chemoselectively oxidizes the N-terminal amine of a… (More)
DOI: 10.1021/ja408868a

5 Figures and Tables

Topics

  • Blog articles referencing this paper

  • Presentations referencing similar topics