Site-specific protein transamination using N-methylpyridinium-4-carboxaldehyde.


The controlled attachment of synthetic groups to proteins is important for a number of fields, including therapeutics, where antibody-drug conjugates are an emerging area of biologic medicines. We have previously reported a site-specific protein modification method using a transamination reaction that chemoselectively oxidizes the N-terminal amine of a… (More)
DOI: 10.1021/ja408868a

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