Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA.

@article{Szalai2002SitespecificPO,
  title={Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA.},
  author={Veronika A. Szalai and Melissa J Singer and Herbert H. Thorp},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 8},
  pages={
          1625-31
        }
}
Telomeres at the ends of human chromosomes contain the repeating sequence 5'-d[(TTAGGG)(n)]-3'. Oxidative damage of guanine in DNAs that contain telomeric and nontelomeric sequence generates 7,8-dihydro-8-oxoguanine (8OG) preferentially in the telomeric segment, because GGG sequences are more reactive in duplex DNA. We have developed a general strategy for probing site-specific oxidation reactivity in diverse biological structures through substitution of minimally modified building blocks that… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Dna Glycosylases Remove Oxidized Base Damages From G-Quadruplex Dna Structures

VIEW 11 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

The role of telomere binding molecules for normal and abnormal hematopoiesis.

  • International journal of hematology
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

G-quadruplexes in human promoters: A challenge for therapeutic applications.

  • Biochimica et biophysica acta. General subjects
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers

Loading similar papers…