Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein.

@article{Durkin2006SitespecificPD,
  title={Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein.},
  author={Sarah S. Durkin and Michael Ward and Kimberly A. Fryrear and O. John Semmes},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 42},
  pages={31705-12}
}
The human T-cell leukemia virus type 1 oncoprotein Tax is a phosphoprotein with a predominately nuclear subcellular localization that accomplishes multiple functions via protein-protein interactions. It has been proposed that regulation of this protein's pleiotropic functions may be accomplished through phosphorylation of specific amino acid residues. We have conducted a phosphoryl mapping of mammalian-expressed Tax protein using a combination of affinity purification, liquid chromatography… CONTINUE READING
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