Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes.

@article{Canovas2018SitespecificNF,
  title={Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes.},
  author={Coline Canovas and Pierre-Simon Bellaye and Mathieu Moreau and Anthony Romieu and Franck Denat and Victor Goncalves},
  journal={Organic \& biomolecular chemistry},
  year={2018},
  volume={16 45},
  pages={
          8831-8836
        }
}
Near-infrared (NIR) fluorescence imaging is a promising new medical imaging modality. Associated with a targeting molecule, NIR fluorophores can accumulate selectively in tissues of interest and become valuable tools for the diagnosis and therapy of various pathologies. To facilitate the design of targeted NIR imaging agents, it is important to identify simple and affordable fluorescent probes, allowing rapid labelling of biovectors such as proteins, ideally in a site-specific manner. Here, we… 
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